Novel Therapies for Pancreatic Cancer.

Pancreatic adenocarcinoma (PDAC) unfortunately remains a highly fatal disease with a 5-year survival rate of only 11%. If surgical resection is not possible, systemic chemotherapy represents the standard-of-care approach to management. Combination chemotherapy regimens using fluorouracil (fluorouracil, oxaliplatin, leucovorin, and irinotecan; and fluorouracil, leucovorin, and oxaliplatin) or gemcitabine with albumin-bound paclitaxel have the potential to improve overall survival for patients with advanced disease.

Inpatient Gastroenterology Consults Have Little Utility Before Transesophageal Echocardiograms in a Prospective Cohort Study.

Introduction: Despite the well-documented safety of transesophageal echocardiograms (TEEs), inpatient gastroenterology (GI) services are called to clear patients for the procedure when they have GI symptoms or comorbidities ranging from mild to clinically significant. We aimed to assess the clinical utility of such consults in preventing TEE complications.

Methods: We performed a prospective cohort study of all inpatients at our institution who had a TEE ordered from 7/1/2021 through 7/1/2022.

Soliton synchronization in microresonators with a modulated pump.

Microresonator frequency comb generation from Kerr solitons has become a cutting edge technology, but challenges remain in creating, maintaining, and controlling the solitons. Pump modulation and dual pumping are promising techniques for meeting these challenges. Here we derive the equation of motion of solitons interacting with a modulated pump in the framework of synchronization theory.

Heart-to-heart: infant heart rate at 3 months is linked to infant-directed speech, mother-infant interaction, and later language outcomes.

Introduction: Previous studies underscore the importance of speech input, particularly infant-directed speech (IDS) during one-on-one (1:1) parent-infant interaction, for child language development. We hypothesize that infants' attention to speech input, specifically IDS, supports language acquisition. In infants, attention and orienting responses are associated with heart rate deceleration.

Infants' brain responses to social interaction predict future language growth.

In face-to-face interactions with infants, human adults exhibit a species-specific communicative signal. Adults present a distinctive "social ensemble": they use infant-directed speech (parentese), respond contingently to infants' actions and vocalizations, and react positively through mutual eye-gaze and smiling. Studies suggest that this social ensemble is essential for initial language learning.