Publications by authors named "J Milgrom"
The understanding of long-term depression and anxiety trajectories across the perinatal periods is lacking. This longitudinal study investigated the change trajectories of both depressive and anxiety symptoms, as well as the associations of their trajectories over five years. The study included nulliparous participants (N = 163, M = 33.
View Article and Find Full Text PDFIntroduction: Major depression (MD) is more common amongst women than men, and MD episodes have been associated with fluctuations in reproductive hormones amongst women. To investigate biological underpinnings of heterogeneity in MD, the associations between depression, stratified by sex and including perinatal depression (PND), and blood biomarkers, using UK Biobank (UKB) data, were evaluated, and extended to include the association of depression with biomarker polygenic scores (PGS), generated as proxy for each biomarker.
Method: Using female ( = 39,761) and male ( = 38,821) UKB participants, lifetime MD and PND were tested for association with 28 blood biomarkers.
Article Synopsis
- The study focuses on postpartum depression (PPD), a hereditary form of major depressive disorder, using genome-wide association studies (GWAS) to explore its genetic basis across various populations.
- It analyzed data from 18,770 PPD cases and 58,461 controls, finding no single-nucleotide polymorphisms (SNPs) that met genome-wide significance, though it highlighted significant genetic correlations with other mental health conditions.
- The findings suggest that PPD is polygenic and heritable, potentially involving unique genetic factors despite its close relationship with major depressive disorder and implicate specific brain neurons associated with its treatment.
Background: Substantial evidence indicates that maternal depression during pregnancy (i.e., antenatal depression) is associated not only with maternal wellbeing but also with child emotional and behavioural development.
View Article and Find Full Text PDFTrait anger reflects a tendency to feel irritation, annoyance, and rage, and involves a narrowing of cognition and attention. This narrowed scope may impact the capacity to understand the mental states of oneself and others (mentalizing), which for fathers of infants may compromise bonding and caregiving involvement. Here, we investigated the extent to which mentalizing mediated the relationship between father trait anger and both father-infant bonding and father involvement in infant caregiving.
View Article and Find Full Text PDF