Management of Patients with Relapsed and/or Refractory Multiple Myeloma Treated with Novel Combination Therapies in Routine Clinical Practice in Germany.

Introduction: Multiple myeloma remains an incurable plasma cell malignancy which, despite improvements in overall survival over the last decade, is characterized by recurrent relapse and is associated with a poor prognosis. This study investigates the use of novel agents in current real-world clinical practice in the management of relapsed and/or refractory multiple myeloma (RRMM) in Germany over different lines of therapy.

Methods: A retrospective chart review was conducted for patients with RRMM treated at multiple centers across Germany between May 2017 and June 2018.

Prevalence and clinical features of opioid-induced constipation in the general population: A French study of 15,000 individuals.

Background: Constipation is common during opioid therapy and can compromise analgesia.

Aim: The aim of this article is to determine the prevalence and clinical characteristics of opioid-induced constipation (OIC) in France.

Methods: A questionnaire study was conducted in a representative sample of the French general population.