Publications by authors named "J Miholic"
Objective: The pancreatic uptake of [C]methionine ([C]MET) is associated with beta-cell function and insulin secretion, but [C]MET uptake and its relationship with exocrine pancreatic performance are less well studied. The postprandial release of cholecystokinin (CCK) depends on gastric emptying velocity and triggers exocrine pancreas secretion. Therefore, we assumed that high postprandial CCK concentrations stimulate the uptake of [C]MET in the residual pancreas following pancreaticoduodenectomy.
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- New-onset diabetes often improves after pancreaticoduodenectomy (PD), possibly due to increased production of glucagon-like peptide-1 (GLP-1) caused by changes in digestion.
- The study involved comparing GLP-1 release in 15 patients who had a Whipple procedure versus 15 who had pylorus-preserving surgery, measuring various blood markers after a test meal.
- Results showed that faster gastric emptying and the type of surgery were linked to higher GLP-1 levels, and patients with Whipple surgery had better blood sugar control compared to those with pylorus preservation.
Background: Patients with gastroesophageal reflux disease (GERD) also frequently suffer from concomitant hiatal hernia. It has been described that a preoperative hiatal hernia of ≥3 cm is associated with a more than threefold relative risk for reflux symptom recurrence after fundoplication without mesh reinforcement. In this report, we describe our experience with the implantation of dual-sided composite PTFE/ePTFE meshes in a tension-free fashion during laparoscopic antireflux surgery (LARS).
View Article and Find Full Text PDFPurpose: [S-methyl-C]-L-methionine ([C]MET) uptake in the pancreas might be a central indicator of beta cell function. Since gastric emptying was recently shown to influence glycemic control in subjects after pancreaticoduodenectomy (PD, the surgical treatment of neoplasms of the pancreas head), we looked for imaginable relationships between gastric emptying, pre- and postprandial insulin concentrations, and [C]MET uptake.
Methods: Nineteen tumor-free survivors after PD (age mean ± SD: 61 ± 8.