Dual inhibition of P38 MAPK and JNK pathways preserves stemness markers and alleviates premature activation of muscle stem cells during isolation.

Background: Adult skeletal muscle contains resident muscle stem cells (MuSC) with high myogenic and engraftment potentials, making them suitable for cell therapy and regenerative medicine approaches. However, purification process of MuSC remains a major hurdle to their use in the clinic. Indeed, muscle tissue enzymatic dissociation triggers a massive activation of stress signaling pathways, among which P38 and JNK MAPK, associated with a premature loss of MuSC quiescence.

Toward machine-assisted tuning avoiding the underestimation of uncertainty in climate change projections.

Documenting the uncertainty of climate change projections is a fundamental objective of the inter-comparison exercises organized to feed into the Intergovernmental Panel on Climate Change (IPCC) reports. Usually, each modeling center contributes to these exercises with one or two configurations of its climate model, corresponding to a particular choice of "free parameter" values, resulting from a long and often tedious "model tuning" phase. How much uncertainty is omitted by this selection and how might readers of IPCC reports and users of climate projections be misled by its omission? We show here how recent machine learning approaches can transform the way climate model tuning is approached, opening the way to a simultaneous acceleration of model improvement and parametric uncertainty quantification.

Non-linear loss of suitable wine regions over Europe in response to increasing global warming.

Evaluating the potential climatic suitability for premium wine production is crucial for adaptation planning in Europe. While new wine regions may emerge out of the traditional boundaries, most of the present-day renowned winemaking regions may be threatened by climate change. Here, we analyse the future evolution of the geography of wine production over Europe, through the definition of a novel climatic suitability indicator, which is calculated over the projected grapevine phenological phases to account for their possible contractions under global warming.

Early warning signal for a tipping point suggested by a millennial Atlantic Multidecadal Variability reconstruction.

Atlantic multidecadal variability is a coherent mode of natural climate variability occurring in the North Atlantic Ocean, with strong impacts on human societies and ecosystems worldwide. However, its periodicity and drivers are widely debated due to the short temporal extent of instrumental observations and competing effects of both internal and external climate factors acting on North Atlantic surface temperature variability. Here, we use a paleoclimate database and an advanced statistical framework to generate, evaluate, and compare 312 reconstructions of the Atlantic multidecadal variability over the past millennium, based on different indices and regression methods.

Increased risk of near term global warming due to a recent AMOC weakening.

Some of the new generation CMIP6 models are characterised by a strong temperature increase in response to increasing greenhouse gases concentration. At first glance, these models seem less consistent with the temperature warming observed over the last decades. Here, we investigate this issue through the prism of low-frequency internal variability by comparing with observations an ensemble of 32 historical simulations performed with the IPSL-CM6A-LR model, characterized by a rather large climate sensitivity.