Publications by authors named "J Miedler"
Triple-negative breast cancer comprises 10% to 15% of newly diagnosed breast cancer and lacks expression of the estrogen, progesterone, and human epidermal growth factor receptor 2/neu receptors. Many such tumors are basal like, a molecular intrinsic subtype of breast cancer associated with poor clinical outcomes. Patients with early-stage basal-like triple-negative breast cancer are at a high risk for relapse and may, therefore, benefit from novel therapies, including immunotherapy.
View Article and Find Full Text PDFArticle Synopsis
- Id reaction, or autoeczematization, is a type of dermatitis that appears away from the initial site of irritation or infection, usually presenting as intensely itchy rashes on the extremities.
- This condition commonly showcases spongiotic dermatitis with possible eosinophil presence and can be triggered by skin inflammations or infections like mycobacterial infections.
- A case study highlighted a 90-year-old man experiencing an itchy, scaly rash on his limbs after starting BCG therapy for bladder cancer, which improved after stopping the treatment and using corticosteroids.
We identified 11 patients with CD10(+) cutaneous T-cell lymphoma by flow cytometry. All cases were CD4(+) and CD8(-). Three patients had extensive lymphadenopathy, systemic symptoms and an aggressive clinical course consistent with angioimmunoblastic T-cell lymphoma or peripheral T-cell lymphoma.
View Article and Find Full Text PDFBackground: Most actinic keratoses (AKs) respond to standard treatments, but a subset persist and require further intervention. We report a series of 10 patients with AKs that failed to respond to conventional treatment with cryotherapy and topical monotherapy but responded completely to simultaneous therapy with topical 5-fluorouracil (5-FU) and imiquimod creams.
Objective: To report the success of this combination therapy in refractory AKs and to determine whether any clinical or histologic features predict for treatment resistance.