Publications by authors named "J Michael Spivey"
The preparation of sodium isopropyl(trimethylsilyl)amide (NaPTA), sodium (1-phenylethyl)(trimethylsilyl)amide (NaPETA), sodium -butyl(trimethylsilyl)amide (NaBTA), and isotopologues [N]NaPTA and [N]NaBTA are described. Solution structural studies using a combination of Si NMR spectroscopy, the Method of Continuous Variations, and density functional theory computations provided insights into aggregation and solvation in a range of solvents including toluene, ,-dimethylethylamine, triethylamine, MTBE, THF, 1,2-dimethoxyethane (DME), diglyme, ,,','-tetramethylethylenediamine (TMEDA), ,,','-tetramethylcyclohexanediamine (TMCDA), ,,',″,″-pentamethyldiethylenetriamine (PMDTA). 12-crown-4, 15-crown-5, and 18-crown-6 revealed solvent- and substituent-dependent dimer-monomer mixtures with affiliated solvation numbers.
View Article and Find Full Text PDFEffect of automated identification of antimicrobial stewardship opportunities for suspected urinary tract infections.
Antimicrob Steward Healthc Epidemiol
October 2024
Article Synopsis
- - Automated identification of antibiotics for suspected urinary tract infections (UTIs) was implemented to see if it could speed up antimicrobial stewardship (AS) interventions in a hospital setting.
- - A study comparing data before and after the introduction of a best practice alert (BPA) found that the median time to intervention decreased from 28 hours to 16 hours, with a significant increase in UTI-related interventions.
- - The results suggest that while the BPA improved the efficiency of AS reviews, some cases still needed in-depth clinical review to address concerns like gram-negative bacteremia from urinary sources.
Article Synopsis
- Ovine pulmonary adenocarcinoma (OPA) is a serious lung disease in sheep that affects their health and costs farmers money.* -
- Scientists created a model to study OPA by giving sheep a virus called JSRV, and they found that different amounts of the virus led to various types of tumors.* -
- They used imaging techniques like CT scans and ultrasounds to monitor the tumors, discovering that these tools can effectively track the disease's progress, which helps improve research.*
Solution structures of potassium hexamethyldisilazide [KHMDS] and labeled [N]KHMDS were examined using a number of analytical methods including Si NMR spectroscopy and density functional theory computations. A combination of N-Si couplings, Si chemical shifts, and the method of continuous variations reveals dimers, monomers, and ion pairs. Weakly coordinating monofunctional ligands such as toluene, -dimethylethylamine, and EtN afford exclusively dimers.
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