Why Teens Don't Talk: Understanding the Role of Stigma Within Barriers to Help Seeking.

The stigma of mental illness, among a larger set of barriers to help seeking, has been understudied among teens. These barriers and the sources of support were examined through an online survey with 1,428 U.S.

Discovery of BIIB068: A Selective, Potent, Reversible Bruton's Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases.

Autoreactive B cell-derived antibodies form immune complexes that likely play a pathogenic role in autoimmune diseases. In systemic lupus erythematosus (SLE), these antibodies bind Fc receptors on myeloid cells and induce proinflammatory cytokine production by monocytes and NETosis by neutrophils. Bruton's tyrosine kinase (BTK) is a non-receptor tyrosine kinase that signals downstream of Fc receptors and plays a transduction role in antibody expression following B cell activation.

Toxicity and Efficacy of Stereotactic Ablative Body Radiotherapy for Moderately Central Non-small Cell Lung Cancers Using 50 Gy in Five Fractions.

Aims: Stereotactic ablative body radiotherapy doses for peripheral lung lesions caused high toxicity when used for central non-small cell lung cancer (NSCLC). To determine a safe stereotactic ablative body radiotherapy dose for central tumours, the phase I/II Radiation Therapy Oncology Group RTOG 0813 trial used 50 Gy/five fractions as a baseline. From 2013, 50 Gy/five fractions was adopted at the Beatson West of Scotland Cancer Centre for inoperable early stage central NSCLC.

Five-year performance monitoring of a high-density polyethylene (HDPE) cover system at a reclaimed mine waste rock pile in the Sydney Coalfield (Nova Scotia, Canada).

Cover systems are commonly placed over waste rock piles (WRPs) to limit atmospheric water and oxygen ingress and control the generation and release of acid mine drainage (AMD) to the receiving environment. Although covers containing geomembranes such as high-density polyethylene (HDPE) exhibit the attributes to be highly effective, there are few, if any, published studies monitoring their performance at full-scale WRPs. In 2011, a HDPE cover was installed over the Scotchtown Summit WRP in Nova Scotia, Canada, and extensive field performance monitoring was conducted over the next five years.