Publications by authors named "J Michael Leger"
Background: Anorexia nervosa (AN) is a serious multifactorial eating disorder characterized by insufficient nutritional intake to maintain a minimum normal weight for one's age and height, a fear of gaining weight and a distorted body image. It affects mainly adolescents, but a decreased age at diagnosis has been reported, leading to the definition of a rare form of AN called early-onset or prepubertal anorexia nervosa (EOAN; ORPHA 525738), with reported epidemiological and clinical specificity. Current knowledge and specific treatments for this particular condition remain scarce.
View Article and Find Full Text PDFJames Leger pays tribute to former Optics Express Editor-in-Chief, Andrew Weiner.
View Article and Find Full Text PDFBackground: Midlife and older women who experience intimate partner violence (IPV) often have less access to supports and services than younger women. There is far less focus on research and supports for midlife and older women compared to younger women experiencing IPV, and often, neither elder abuse nor IPV services meet their needs. Few interventions are available to meet the needs of midlife and older women.
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- NKX2-1 is a critical transcription factor linked to rare disorders that cause thyroid, lung, and brain issues, with early diagnosis being key for effective treatment.
- This systematic review analyzes the effectiveness of Levothyroxine (LT4) treatment for NKX2-1-related disorders, focusing on congenital hypothyroidism, treatment initiation, and dosage variations.
- Findings reveal that congenital hypothyroidism is common in these patients, yet LT4 is initiated in only 10%, with significant reliance on age at diagnosis affecting treatment outcomes.
Article Synopsis
- * A systematic review analyzed 1012 studies, ultimately including 46 that focused on screening and diagnosing endocrine issues related to NKX2-1-RD in patients, revealing that 45% had congenital hypothyroidism.
- * The findings indicated inconsistent diagnostic practices, with a significant number of patients diagnosed in adulthood and a need for standardized screening and diagnostic procedures for better management of endocrine disorders associated with NKX2-1-RD.