First Measurement of Missing Energy due to Nuclear Effects in Monoenergetic Neutrino Charged-Current Interactions.

We present the first measurement of the missing energy due to nuclear effects in monoenergetic, muon neutrino charged-current interactions on carbon, originating from K^{+}→μ^{+}ν_{μ} decay at rest (E_{ν_{μ}}=235.5  MeV), performed with the J-PARC Sterile Neutrino Search at the J-PARC Spallation Neutron Source liquid scintillator based experiment. Toward characterizing the neutrino interaction, ostensibly ν_{μ}n→μ^{-}p or ν_{μ}^{12}C→μ^{-}^{12}N, we define the missing energy as the energy transferred to the nucleus (ω) minus the kinetic energy of the outgoing proton(s), E_{m}≡ω-∑T_{p}, and relate this to visible energy in the detector, E_{m}=E_{ν_{μ}}(235.

Clinical features of secondary BPPV: A nation-wide multicenter study.

BackgroundBenign paroxysmal positional vertigo (BPPV) is the most common peripheral vestibular disorder, and its prevalence is substantial. While primary BPPV has been well studied, the understanding of secondary BPPV is still limited.ObjectiveTo investigate the prevalence and clinical characteristics of secondary BPPV in a national multicenter retrospective analysis.

Inhibiting EZH2 complements steroid effects in Duchenne muscular dystrophy.

Duchenne muscular dystrophy (DMD) is a devastating X-linked disorder caused by dystrophin gene mutations. Despite recent advances in understanding the disease etiology and applying emerging treatment methodologies, glucocorticoid derivatives remain the only general therapeutic option that can slow disease development. However, the precise molecular mechanism of glucocorticoid action remains unclear, and there is still need for additional remedies to complement the treatment.

Metal-Phenolic Coordination mediated Nanoemulsions for All-in-One Drug Delivery.

Combination chemotherapy is a promising strategy for cancer treatment, enhancing antitumor efficacy while minimizing drug resistance and mitigating the risk of single-drug overdose toxicity. Polymeric drug delivery carriers for combination chemotherapy have been developed; however, the synthetic process of amphiphilic polymers is time-consuming and laborious. The polymer entanglement-based drug encapsulation has been limited in achieving a high multidrug encapsulation efficiency because of the intrinsic preference for encapsulation of drugs upon their polarity.

Exploring Community-Based Residency Programs in High-Need Black Counties.

Background And Objectives: Primary care physician (PCP) shortages and uneven geographic distribution are well-documented. Black populations have less access to primary care and worse health outcomes, with a lack of provider-patient racial concordance playing a role. Addressing these disparities requires targeted approaches that produce more Black PCPs in high-need areas, including expanding community-based residency programs (CBRPs), which are more likely to produce physicians in high-need areas.