Publications by authors named "J Mi"
Background And Purpose: This study evaluates the dosimetric impact of tumor matching (TM) and bone matching (BM) in carbon ion radiotherapy for locally advanced non-small cell lung cancer.
Materials And Methods: Forty patients diagnosed with locally advanced non-small cell lung cancer were included in this study. TM and BM techniques were employed for recalculation based on re-evaluation computed tomography (CT) images of the patients, resulting in the generation of dose distributions: Plan-T and Plan-B, respectively.
The aqueous extract of Murray (LRE) could attenuate neuroinflammation in mice induced by a high-fat and high-fructose diet (HFFD). Moreover, LRE could adjust bile acid (BA) metabolism and the gut microbiota. Behavioral tests revealed that LRE prevented HFFD-induced cognitive deficits.
View Article and Find Full Text PDFBackground & Aims: Accumulating evidence suggests that exposure to single heavy metal can facilitate the progression of age-related macular degeneration (AMD). However, the effects of exposure to mixtures of heavy metals on AMD remain largely unexplored. This study aims to investigate both the joint and individual impacts of arsenic (As), mercury (Hg), cadmium (Cd), and lead (Pb) on AMD within a co-exposure framework.
View Article and Find Full Text PDFMTAF-DTA: multi-type attention fusion network for drug-target affinity prediction.
BMC Bioinformatics
December 2024
Article Synopsis
- The development of drug-target binding affinity (DTA) prediction is evolving from traditional lab methods to machine learning, enhancing drug discovery by saving time and resources.
- A new method called MTAF-DTA improves DTA prediction by using an attention mechanism to assess the importance of different drug features and simulating drug-target interactions through a Spiral-Attention Block.
- MTAF-DTA outperforms existing methods, demonstrating improved predictive accuracy in experiments, suggesting its potential for practical applications in drug discovery and treatment.
Article Synopsis
- * Researchers analyzed OC cells under different oxygen conditions and measured the expression of PFKP and PTEN using various scientific methods.
- * Findings showed that higher PFKP levels in OC tissues boost glycolysis and tumor growth, while reducing PFKP led to increased PTEN expression and decreased glycolytic activity, indicating a potential therapeutic target for treating OC.