An Expanded Registry of Candidate cis-Regulatory Elements for Studying Transcriptional Regulation.

Mammalian genomes contain millions of regulatory elements that control the complex patterns of gene expression. Previously, The ENCODE consortium mapped biochemical signals across many cell types and tissues and integrated these data to develop a Registry of 0.9 million human and 300 thousand mouse candidate cis-Regulatory Elements (cCREs) annotated with potential functions .

False-Positive Phosphatidylethanol Results Due to Blood Transfusion and Implications in the Process of Liver Transplantation Selection.

Phosphatidylethanol (PEth) testing is becoming increasingly common as a tool to assess for alcohol consumption in the practice of addiction medicine. Its potential to be an objective measure of ethanol exposure is appealing; however, the field has yet to develop a complete understanding of the factors that can influence a PEth level. Here we describe 3 patient cases in which blood transfusion within the preceding 28 days was the reason that PEth studies were positive in patients undergoing liver transplant evaluation.

Self-injurious thoughts and behaviors among Hispanic/Latine college students in the US: Disaggregating by key sub-group characteristics.

Hispanic/Latine college students are increasingly at high risk to experience self-injurious thoughts and behaviors (SITBs). This brief report examined SITB prevalence rates among a national sample of Hispanic/Latine college students, with specificity to sub-group characteristics. : Hispanic college students across 139 institutions from a national survey of college student mental health (Healthy Minds Study) in the US ( = 12,499).

Therapeutic DNA Vaccine Targeting Persisters Shortens Curative Tuberculosis Treatment.

Unlabelled: Mtb) is one of the leading infectious causes of death worldwide. There is no available licensed therapeutic vaccine that shortens active tuberculosis (TB) disease drug treatment and prevents relapse, despite the World Health Organization's calls. Here, we show that an intranasal DNA vaccine containing a fusion of the stringent response gene with the gene encoding the immature dendritic cell-targeting chemokine, MIP-3α/CCL20, shortens the duration of curative TB treatment in immunocompetent mice.

MIP3α-Rel intranasal DNA vaccination induces reactive T-cell infiltration into the lungs in mice and macaques.

(Mtb), the causative agent of tuberculosis (TB), is the leading cause of mortality due to a single infectious organism. While generally curable, TB requires a lengthy and complex antibiotic regimen, due in large part to bacteria that can shift to a persistent state in the presence of antibiotic pressure. Rel is the primary enzyme regulating the stringent response, which contributes to the metabolic shift of Mtb to a persistent state.