Impact of hyperlipidaemia on the orbital bone cefotaxime levels in rats.

Facial injuries are critical conditions, leading to serious complications, such as occult facial infections. Infectious endophthalmitis occurs despite of antibiotics use during implantation of intraocular lenses and is generally resistant to antibiotic therapy. It is a crucial situation in ophthalmology, since it often induces a substantial reduction of visual acuity and in some cases the loss of the eye despite treatment.

Compensatory adrenal growth in relation to stress of surgery and estradiol in adult male rats.

ACTH infusion at the time of unilateral adrenalectomy inhibits the early rapid compensatory growth (CAG) in the remaining adrenal. We examined the hypothesis that different duration of surgery and/or the enhanced response to the stress of surgery, induced by estradiol treatment, might modify CAG. Adult male rats untreated, estradiol benzoate treated (EB) 300 microg/kg or vehicle treated (VE) for 3 days, were Sham or left adrenalectomized after 18 to 20 min procedure (prolonged surgery) or after 14 to 16 min procedure (short surgery).

Does stress influence ampicillin concentration in serum and tissues?

Exercise produces changes of drug levels in plasma and increases the concentration of free fatty acids (FFAs), which may interfere with drug-protein binding. FFAs seem to play an antagonistic role to drugs since they have a strong binding capacity to serum albumin. The aim of this study was to evaluate the influence of the consecutive exercise-induced stress in ampicillin levels.

Monoaminergic dysregulation on diestrus-2 and estrus through high emotional reactivity.

Rats with great differences in emotional reactivity, during weighing and handling for vaginal smear screening were examined on diestrus-2 (DE-2), proestrus (PE), and estrus (E). Rats with high emotional reactivity (HR), interpreted as trait anxiety, had different serotonergic and dopaminergic profile in hypothalamus-preoptic area (HY-PA) and striatum (Str) and thymus weight lower than that found in rats with low emotional reactivity (LR). In HY-PA of rats with HR when compared to rats with LR, increased 5-hydroxyindoleacetic acid (5-HIAA), 5-HIAA/serotonin (5-HT) ratio, and 3,4-dihydroxyphenylacetic acid (DOPAC) and in Str increased DOPAC and DOPAC/dopamine (DA) ratio were found only on DE-2, paralleled by increased adrenal weight and decreased thymus weight.