Biomarkers.

Background: Magnetic resonance imaging (MRI) has been very useful in evaluating brain atrophy related to Alzheimer's Disease (AD), so it is important to have scales that allow objective evaluation specifically of parietal atrophy. The objective of this study was to develop and validate a modified visual scale for the assessment of parietal atrophy (APM Scale) by brain MRI in a single slice (axial T2-FLAIR), with focus on the measurement of the posterior cingulate sulcus to differentiate between Mild Cognitive Impairment (MCI), AD and other forms of dementia (OD not AD).

Method: retrospective validation study carried out in a memory clinic of a tertiary hospital in Mexico City, in a period from March 2015 to June 2023.

Clinical and preclinical evidence of psilocybin as antidepressant. A narrative review.

In the rapidly growing field of psychedelic research, psilocybin (and active metabolite psilocin) has been proposed as a promising candidate in the search for novel treatments for neuropsychiatric disorders. Clinical trials have revealed that psilocybin has a large, rapid, and persistent effect in the improvement of symptoms of depression and anxiety. The safety profile is considered favourable, with low toxicity and good tolerance.

Uncovering selection pressures on the IRF gene family in bats' immune system.

Unlike other mammals, bats serve as natural reservoirs for several highly pathogenic viruses without exhibiting symptoms of infection. Recent research has explored the complex mechanisms underlying the balance between bats' antiviral defenses and their pathological responses. However, the evolution of the molecular drivers behind bats' antiviral strategies remains largely unknown.

UTX Epigenetically Imposes a Cytolytic Effector Program in Autoreactive Stem-like CD8+ T cell Progenitors.

Type 1 Diabetes Mellitus (T1D) is an autoimmune disease caused by unremitting immune attack on pancreas insulin-producing beta cells. Persistence of the autoimmune response is mediated by TCF1+ Ly108+ progenitor CD8+ T (T) cells, a stem-like population that gives rise to exhausted effectors with limited cytolytic function in chronic virus infection and cancer. What paradoxically drives T conversion to highly cytolytic effectors in T1D, however, remains unclear.