Publications by authors named "J Meinkoth"
Cytauxzoonosis is caused by (), a tick-borne parasite that causes severe disease in domestic cats in the United States. Currently, there is no vaccine to prevent this fatal disease, as traditional vaccine development strategies have been limited by the inability to culture this parasite in vitro. Here, we used a replication-defective human adenoviral vector (AdHu5) to deliver -specific immunogenic antigens and induce a cell-mediated and humoral immune response in cats.
View Article and Find Full Text PDFCytauxzoonosis is an emerging tick-borne disease of domestic and wild felids produced by infection of an apicomplexan protozoan similar to spp. Transmitted by , lone star tick, and , American dog tick, infection of in cats is severe, characterized by depression, lethargy, fever, hemolytic crisis, icterus, and possibly death. Cytauxzoonosis occurs mainly in the southern, south-central, and mid-Atlantic United States in North America, in close association with the distribution and activity of tick vectors.
View Article and Find Full Text PDFArticle Synopsis
- The northern bobwhite quail, a game bird, is facing a population decline throughout its habitat.
- There is a lack of specific hematologic data for this species, especially for juvenile quail, prompting a study on 49-day-old captive-raised quail to establish reference blood values.
- The study recorded various blood parameters, revealing that the quail were mostly lymphocytic but exhibited significant variability, and it noted discrepancies in white blood cell count methods.
Mast cells (MCs) play critical roles in the pathogenesis of IgE- and non-IgE-mediated immune responses, as well as host defense against parasites, bacteria, and viruses. Due to the effect of extracellular matrix components on tissue morphogenesis and cell behavior, utilizing a tissue model that mimics MC microenvironmental conditions has greater relevance for studies. For this work, MCs were developed within a connective tissue-equivalent model and cell function was examined in response to an allergen.
View Article and Find Full Text PDFObjectives: The aim of this study was to describe clinical and diagnostic findings in cats with bone and joint disease associated with histoplasmosis.
Methods: Medical records from between 2011 and 2017 were reviewed. Inclusion criteria required: (1) diagnosis of histoplasmosis by cytology, histology, urine or serum antigen testing, or culture; and (2) lameness or joint effusion as a presenting complaint or physical examination finding.