Ammonia and beyond - biomarkers of hepatic encephalopathy.

Ammonia is a product of amino acid metabolism that accumulates in the blood of patients with liver cirrhosis, leading to neurotoxic effects and hepatic encephalopathy (HE). HE manifestations can range from mild, subclinical disturbances in cognition, or minimal HE (mHE) to gross disorientation and coma, a condition referred to as overt HE. Many blood-based biomarkers reflecting these neurotoxic effects of ammonia and liver disease can be measured in the blood allowing the development of new biomarkers to diagnose cirrhosis patients at risk of developing HE.

Pericytes in Glioblastoma: Hidden Regulators of Tumor Vasculature and Therapy Resistance.

Glioblastoma IDH wild type (GB), the most common malignant primary brain tumor, is characterized by rapid proliferation, extensive infiltration into surrounding brain tissue, and significant resistance to current therapies. Median survival is only 15 months despite extensive clinical efforts. The tumor microenvironment (TME) in GB is highly specialized, supporting the tumor's aggressive behavior and its ability to evade conventional treatments.

Attitudes Toward Prostitution in Norway, Spain, and Germany: Association With the Legal Context and Susceptibility to Persuasion.

The social and legal treatment of prostitution varies between countries. We examined attitudes toward prostitution (ATP) and their susceptibility to persuasion in three countries: Norway, where prostitution is illegal; Spain, where prostitution is not explicitly regulated in the law; and Germany, where prostitution is legal. Participants (total N = 579) read arguments in favor of either legalization or abolition of prostitution or no arguments.

Prevalence and associated factors of intimate partner violence against pregnant women who attend antenatal care in Denmark and Spain: A digital screening approach.

Introduction: Intimate partner violence against women is a global health issue. Exposure to intimate partner violence during pregnancy leads to health-related problems for both the mother and the newborn. However, current knowledge on its occurrence varies widely and assessing the problem using standardized tools in different contexts is needed.

Unveiling the Gender Symmetry Debate: Exploring Consequences, Instructions, and Forms of Violence in Intimate Partner Violence.

Official statistics and data from police and judicial systems consistently show that intimate partner violence (IPV) is a worldwide problem predominantly affecting women perpetrated by male partners. Yet, certain behavioral checklists yield similar IPV rates for both genders, sparking the gender symmetry/asymmetry debate. Some possible explanations for this discrepancy reside in (a) considering or not the consequences of violence, (b) possible inadequacies of the instructions given to participants when answering checklists, and (c) considering or not certain behaviors typically asymmetrical (e.