Publications by authors named "J Medley"
Temporal regulation of gene expression is required for developmental transitions, including differentiation, proliferation, and morphogenesis. In the nematode , heterochronic microRNAs (miRNAs) regulate the temporal expression of genes that promote animal development. The heterochronic miRNAs lin-4 and let-7 are required during different stages of larval development and are associated with the miRNA-specific Argonaute ALG-1.
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- - The COVID-19 pandemic led to social distancing, causing patients to avoid in-office health care visits, which increased reliance on emergency departments for manageable conditions.
- - A study analyzed national ED visit data from 2019 to 2021 and found that the percentage of visits by older adults for ambulatory-care-sensitive conditions (ACSCs) rose from 17.4% to 18.5%.
- - Increased ACSC ED visits were observed in both rural (from 26.4% to 28.6%) and urban areas (from 15.4% to 16.8%), indicating a delay in routine primary care during the pandemic.
Article Synopsis
- - Centrosome number is crucial for maintaining spindle bipolarity and genomic integrity during cell division, with ZYG-1/Plk4 being the key regulator for centrosome assembly.
- - Casein kinase II (CK2) plays a negative regulatory role by phosphorylating ZYG-1, impacting its levels and preventing excess centrosome duplication.
- - Depleting CK2 or preventing its phosphorylation of ZYG-1 results in increased levels of ZYG-1 at centrosomes, leading to centrosome amplification, highlighting the importance of CK2 in controlling centrosome number through protein degradation.
Spindle bipolarity is critical for genomic integrity. Given that centrosome number often dictates mitotic bipolarity, tight control of centrosome assembly is vital for the fidelity of cell division. The kinase ZYG-1/Plk4 is a master centrosome factor that is integral for controlling centrosome number and is modulated by protein phosphorylation.
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