Publications by authors named "J Mckenzie"
This article presents the CONSORT (consolidated standards of reporting trials) extension for cluster randomised crossover trials. A cluster randomised crossover trial involves randomisation of groups of individuals (known as clusters) to different sequences of interventions over time. The design has gained popularity in settings where cluster randomisation is required because it can largely overcome the loss in power due to clustering in parallel cluster trials.
View Article and Find Full Text PDFFast and reliable identification of bacteria directly in clinical samples is a critical factor in clinical microbiological diagnostics. Current approaches require time-consuming bacterial isolation and enrichment procedures, delaying stratified treatment. Here, we describe a biomarker-based strategy that utilises bacterial small molecular metabolites and lipids for direct detection of bacteria in complex samples using mass spectrometry (MS).
View Article and Find Full Text PDFArticle Synopsis
- This study aims to examine the histopathology and outcomes in patients with retinoblastoma who underwent eye enucleation and had neovascular glaucoma (NVG).
- The research included 1,420 total cases from five continents, revealing that 16% of patients with NVG were often at higher risk of severe histopathological findings.
- The findings indicate that NVG is linked to more aggressive forms of the disease and a higher chance of metastasis, emphasizing the need for careful monitoring and treatment in these cases.
Article Synopsis
- The study compared the combination of lenvatinib and pembrolizumab (len + pembro) with traditional chemotherapy for advanced or recurrent endometrial cancer (aEC) in patients who had not previously been treated.
- Results showed that while len + pembro did not statistically outperform chemotherapy in terms of progression-free survival (PFS) or overall survival (OS), it offered similar outcomes, indicating noninferiority.
- The trial involved 842 patients and found median PFS and OS were comparable between the two treatment groups, suggesting len + pembro could be an effective alternative to chemotherapy for this cancer type.