Publications by authors named "J McGoldrick"
Background: Microscopic colitis (MC) is a common cause of chronic diarrhea, predominantly among older adults. Emerging evidence suggests that perturbations of gut microbiome and metabolome may play an important role in MC pathogenesis.
Objective: To comprehensively characterize alterations of the gut microbial and metabolic composition in MC.
Article Synopsis
- Colonic diverticulosis is a common condition, especially in people over 60, and is linked to changes in gut bacteria, but its specific microbial changes in asymptomatic cases are not well understood.
- A study involving 684 adults undergoing colonoscopy analyzed their gut microbiota and found that about 42% had diverticulosis, but the differences in microbial diversity between those with and without the condition were minimal.
- Key microbial species such as Bifidobacterium pseudocatenulatum and Prevotella copri were more abundant in healthy controls, while Roseburia intestinalis and others were enriched in those with diverticulosis, suggesting potential links between gut bacteria, BMI, and diverticulosis status.
Background: Histopathology remains the gold standard for diagnosing and staging metabolic dysfunction-associated steatotic liver disease (MASLD). The feasibility of studying MASLD progression in electronic medical records based on histological features is limited by the free-text nature of pathology reports. Here we introduce a natural language processing (NLP) algorithm to automatically score MASLD histology features.
View Article and Find Full Text PDFEnvironmental exposures are a major risk factor for developing colorectal cancer, and the gut microbiome may serve as an integrator of such environmental risk. To study the microbiome associated with premalignant colon lesions, such as tubular adenomas (TAs) and sessile serrated adenomas (SSAs), we profiled stool samples from 971 participants undergoing colonoscopy and paired these data with dietary and medication history. The microbial signatures associated with either SSA or TA are distinct.
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