Age changes in dopamine levels in the corpus striatum of Albino Swiss (AS) and AS/AGU mutant rats.

The AS/AGU rat is characterised by an ungainly, staggering gait, hind-limb rigidity, whole body tremor and (in older animals) difficulty in initiating movement. Brains of AS and AS/AGU males aged between 3 and 12 months (n = 10 per group) were sectioned transversely on a cryostat (-20 degrees C) to produce two successive cut faces (corresponding approximately to Bregma +1.2 and -0.

Localised degeneration occurs in aged mouse olfactory epithelium.

Olfactory neuroepithelium of adult vertebrates retains a population of basal stem cells capable, throughout life, of dividing and differentiating into mature olfactory receptor neurons (see Farbman, 1994). The rate of turnover of olfactory receptor neurons is influenced, in part, by environmental conditions (Hinds et al. 1984).

Factors associated with shear bond strength of composite resin to human enamel.

The preparation of enamel surfaces before etching by removing 0.5 mm of surface tooth structure is common-place in modern restorative dentistry. This study was designed to measure and compare the shear bond strength of composite resin bonded to prepared and unprepared enamel using various proprietary bonding systems.

Neostriatal dopamine depletion and locomotor abnormalities due to the Albino Swiss rat agu mutation.

The sub-strain of Albino Swiss rat (AS/AGU) is a spontaneous mutation characterised by an ungainly, staggering gait, hindlimb rigidity, whole body tremor and (when symptoms are fully developed) difficulty in initiating movement; it exhibits a progressive decrease in dopaminergic cells within the substantia nigra. A breeding programme involving Albino Swiss (AS) and AS/AGU parent rats was used to produce the F1 offspring of AS x AS/AGU matings and, subsequently, F1 x AS/AGU back crosses. When adult, the movement of all animals was assessed blind by observers on three occasions, each animal being identifiable by a subcutaneous transponder implanted before weaning.

Hormones and the control of porphyrin biosynthesis and structure in the hamster harderian gland.

The hamster Harderian gland seems to present both an excellent model for the control of porphyrin biosynthesis and an unusually robust example of the interrelationship between structure and function. It has been known for some time that 1) the capacity for manufacturing and storing porphyrins and 2) gland histology and ultrastructure are controlled by androgens. Thus, in intact males as well as in gonadectomised animals of either sex treated with androgens, porphyrin synthesis by the Harderian gland is suppressed and the gland tubules characteristically possess two cell types, the cytoplasm of both containing polytubular complexes.