Publications by authors named "J McFadden"
Background: In cattle, dietary choline is fed in a rumen-protected form to bypass ruminal degradation while allowing intestinal absorption of choline. We require data to help us define choline utilization in the dairy cow transitioning from gestation to lactation.
Objectives: The study examined choline methyl group transfer in dairy cattle transitioning from gestation to lactation.
Purpose: Hip fractures in the elderly, especially those discharged to a rehab facility, have historically been associated with poor outcomes. There has yet to be identified which patients have a higher likelihood of a rehab discharge after isolated hip fracture fixation. The purpose of this study was to identify factors that predispose patients to require short or long-term rehab after surgical intervention of traumatic, isolated hip fractures.
View Article and Find Full Text PDFArticle Synopsis
- Researchers successfully used a cell-free protein synthesis (CFPS) system derived from tobacco to recreate the teleocidin biosynthetic pathway, yielding significant production levels of teleocidin B-3.
- They discovered a key interaction between two proteins, TleA and MbtH, which played a role in this biosynthesis.
- Additionally, they developed a method for producing UK-2 diol, a precursor to the valuable UK-2A compound, by reconstructing a complex pathway with ten proteins in a wheat germ CFPS system, showcasing the potential of plant CFPS systems for biosynthetic research.
Article Synopsis
- * A patient with compound heterozygous DDX41 variants exhibited symptoms including bone dysplasia and ichthyosis, and analysis of their skin cells showed reduced DDX41 levels and disruption of immune gene activation.
- * Further studies revealed significant gene dysregulation and increased periostin mRNA in the patient’s cells, indicating that impaired DDX41 function and altered periostin expression likely contribute to the patient's complex disorder.
Article Synopsis
- A significant outbreak of blastomycosis, a serious fungal infection, occurred among workers at a paper mill in Delta County, Michigan, affecting 131 patients from December 2022 to July 2023.
- Hospitalization rates were notable, with 12% requiring hospitalization, and factors like diabetes and elevated urine antigen levels were linked to more severe cases.
- This outbreak is the largest recorded in the U.S., highlighting the importance of early diagnosis to avoid unnecessary antibiotic use and improve treatment outcomes.