Extreme climatic events to intensify over the Lake Victoria Basin under global warming.

This paper presents an analysis of future precipitation patterns over the Lake Victoria Basin, East Africa, using bias-corrected CMIP6 model projections. A mean increase of about 5% in mean annual (ANN) and seasonal [March-May (MAM), June-August (JJA), and October-December (OND)] precipitation climatology is expected over the domain by mid-century (2040-2069). The changes intensify towards the end of the century (2070-2099) with an increase in mean precipitation of about 16% (ANN), 10% (MAM), and 18% (OND) expected, relative to the 1985-2014 baseline period.

Depth and habitat are important drivers of abundance for predatory reef fish off Pemba Island, Tanzania.

Coral reefs across the world face significant threats from fishing and climate change, which tends to be most acute in shallower waters. This is the case off Pemba Island, Tanzania, yet the effects of these anthropogenic stressors on the distribution and abundance of economically and ecologically important predatory reef fish, including how they vary with depth and habitat type, is poorly understood. Thus, we deployed 79 baited remote underwater videos (BRUVs) in variable water depths and habitats off Pemba Island, and modeled the effects of depth and habitat on abundance of predatory reef fish.

Prospective evaluation of accuracy of HIV viral load monitoring using the Aptima HIV Quant Dx assay with fingerstick and venous dried blood spots prepared under field conditions in Kenya.

Quantification of HIV-1 RNA is essential for clinical management of HIV patients. The limited throughput and significant hands-on time required by most HIV Viral load (VL) tests makes it challenging for laboratories with high test volume, to turn around patient results quickly. The Hologic Aptima HIV-1 Quant Dx Assay (Aptima), has the potential to alleviate this burden as it is high throughput and fully automated.

Performance evaluation of the Aptima HIV-1 Quant Dx assay for detection of HIV in infants in Kenya.

Background: Early infant diagnosis (EID) of HIV-1 exposed infants enables timely initiation of antiretroviral therapy (ART), thereby allowing early diagnosis and treatment to slow disease progression and reduce mortality. Turn-around time to results, partially caused by low to medium throughput technology, remains a hindrance to early treatment. A major solution to this challenge is to incorporate high throughput and accurate technologies in the testing process.

Performance and usability of mPIMA™ HIV 1/2 viral load test in point of care settings in Kenya.

Background: HIV viral load testing is the standard of care for monitoring antiretroviral therapy. In resource-limited settings such as Kenya, access to HIV viral load monitoring is suboptimal due to reliance on centralized laboratory based in vitro diagnostics. Point of care technologies have the potential to improve access and reduce test to result turnaround time.