A mixed methods study on poisoning and injury-related emergency department visits associated with opioids in Canada, 2011 to 2022: from the Canadian hospitals injury reporting and prevention program.

Background: The opioid crisis is a serious public health issue in Canada. There have been many surveillance programs and research studies on opioid-related emergency department (ED) visits at a national, provincial, regional or municipal level. However, no published studies have investigated the in-depth contexts surrounding opioid-related ED visits.

An inducible genetic tool to track and manipulate specific microglial states reveals their plasticity and roles in remyelination.

Recent single-cell RNA sequencing studies have revealed distinct microglial states in development and disease. These include proliferative-region-associated microglia (PAMs) in developing white matter and disease-associated microglia (DAMs) prevalent in various neurodegenerative conditions. PAMs and DAMs share a similar core gene signature.

Precise Predictions for the Associated Production of a W Boson with a Top-Antitop Quark Pair at the LHC.

The production of a top-antitop quark pair in association with a W boson (tt[over ¯]W) is one of the heaviest signatures currently probed at the Large Hadron Collider. Since the first observation reported in 2015, the corresponding rates have been found to be consistently higher than the standard model predictions, which are based on next-to-leading order calculations in the QCD and electroweak interactions. We present the first next-to-next-to-leading order QCD computation of tt[over ¯]W production at hadron colliders.

Skull bone marrow channels as immune gateways to the central nervous system.

Decades of research have characterized diverse immune cells surveilling the CNS. More recently, the discovery of osseous channels (so-called 'skull channels') connecting the meninges with the skull and vertebral bone marrow has revealed a new layer of complexity in our understanding of neuroimmune interactions. Here we discuss our current understanding of skull and vertebral bone marrow anatomy, its contribution of leukocytes to the meninges, and its surveillance of the CNS.

Higgs Boson Production in Association with a Top-Antitop Quark Pair in Next-to-Next-to-Leading Order QCD.

The associated production of a Higgs boson with a top-antitop quark pair is a crucial process at the LHC since it allows for a direct measurement of the top-quark Yukawa coupling. We present the computation of the radiative corrections to this process at the next-to-next-to-leading order (NNLO) in QCD perturbation theory. This is the very first computation for a 2→3 process with massive colored particles at this perturbative order.