Publications by authors named "J Mays"
Objective: To investigate the effects of oral baricitinib on ocular surface disease (OSD) in patients with chronic graft-versus-host disease (cGVHD).
Design: Prospective phase 1 to 2 single institution trial.
Subjects: Eighteen patients with ocular graft-versus-host-disease (oGVHD) and systemic steroid-refractory cGVHD.
Article Synopsis
- * The condition starts when the transplanted cells recognize the recipient's body as foreign, leading to inflammatory responses and potential organ damage.
- * This review covers the latest understanding of cGvHD's development, diagnosis, and treatment options, highlighting new therapies and insights from clinical research and expert opinions.
Article Synopsis
- Investigating chromosomal instability and aneuploidy is crucial for understanding how tumors develop and creating better diagnostic and treatment methods.
- The new method, KaryoTap, combines targeted DNA sequencing with advanced computational tools to efficiently detect chromosomal gains, losses, and neutral variants across thousands of single cells.
- KaryoTap shows high accuracy in identifying chromosomal changes and has the potential to enhance research on aneuploidy in both tumor and normal cells, enabling functional screening with CRISPR technology.
Article Synopsis
- * The research found that tissue samples from patients showed strong IFN-I (a type of immune response) activity and signs of inflammation, even when the virus was only minimally present in biopsies.
- * Additionally, an experiment using hamsters demonstrated that while the virus was active in the lungs, local IFN-I responses occurred in other areas (like toes) without the body developing traditional immunity to the virus, suggesting a potential viral trigger for some pernio cases.
Purpose: Whether and how the oral microbiome and its changes in allogeneic hematopoietic cell transplantation (alloHCT) recipients may contribute to oral chronic GVHD (cGVHD) pathogenesis is unknown. In addition, although the oral and colonic microbiota are distinct in healthy adults, whether oral microbes may ectopically colonize the gut in alloHCT patients is unknown.
Experimental Design: To address these knowledge gaps, longitudinal oral and fecal samples were collected prospectively in the multicenter Close Assessment and Testing for Chronic GVHD study (NCT04188912).