Publications by authors named "J Mayerle"
Article Synopsis
- Bacterial infections are a major issue for patients with cirrhosis, impacting their overall health due to their role in increasing morbidity and mortality.
- This study investigates the role of cytosolic phospholipase A2 (cPLA2) in the activation of human Kupffer cells (HKCs) by gram-negative bacteria, specifically looking at how E. coli influences HKC activation through specific signaling pathways.
- The findings suggest that cPLA2 is crucial for HKC activation in response to E. coli, linking its activity to the regulation by transcription factors STAT3 and RelB via the ERK and non-canonical NF-κB signaling pathways, potentially paving the way for therapeutic strategies in managing bacterial infections in cirrhotic patients
Trypsin in pancreatitis: The culprit, a mediator, or epiphenomenon?
World J Gastroenterol
November 2024
Pancreatitis is a common, life-threatening inflammatory disease of the exocrine pancreas. Its pathogenesis remains obscure, and no specific or effective treatment is available. Gallstones and alcohol excess are major etiologies of pancreatitis; in a small portion of patients the disease is hereditary.
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