Publications by authors named "J Mattumpuram"
Background: Giant cell myocarditis (GCM) and cardiac sarcoidosis (CS) are rare inflammatory diseases of the myocardium with poor prognosis. Cardiovascular disease outcomes among both diseases have not been well studied with limited literature.
Objective: This study aims to investigate the cardiovascular outcomes among patients with GCM and CS.
Article Synopsis
- Colchicine has shown some effectiveness in reducing adverse cardiovascular events (ACE) and myocardial infarctions (MI) in patients with coronary artery disease, but its impact on stroke risk is unclear, with conflicting results.
- A systematic review of 16 randomized controlled trials involving nearly 25,000 patients revealed that while colchicine significantly lowered ACE and MI risks by 33% and 21% respectively, it did not significantly affect stroke incidence or mortality rates.
- Overall, colchicine might be beneficial for certain cardiovascular outcomes, but it does not appear to reduce the risk of stroke or affect mortality rates in the studied population.
Background: The latest guidelines advocate for catheter ablation (CA) over standard medical therapy (SMT) for managing atrial fibrillation (AF) in patients with heart failure with reduced ejection fraction (HFrEF). However, significant knowledge gaps exist regarding the effectiveness of CA vs. SMT in patients with heart failure with preserved ejection fraction (HFpEF).
View Article and Find Full Text PDFWe aim to analyze past literature to evaluate the efficacy of coenzyme Q10 (CoQ-10) in the population with heart failure (HF). A systematic literature search was conducted through MEDLINE (via PubMed) and Cochrane Library. The outcomes analyzed were a reduction in HF-related mortality, an improvement in exercise capacity, and the left ventricular ejection fraction (LVEF).
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