TRPC1 links calcium signaling to cellular senescence in the protection against post-traumatic osteoarthritis.

Transient receptor potential channel 1 (TRPC1) is a widely expressed mechanosensitive ion channel located within the endoplasmic reticulum membrane, crucial for refilling depleted internal calcium stores during activation of calcium-dependent signaling pathways. Here, we demonstrate that TRPC1 activity is protective within cartilage homeostasis in the prevention of cellular senescence associated cartilage breakdown during mechanical and inflammatory challenge. We reveal that TRPC1 loss is associated with early stages of osteoarthritis (OA) and plays a non-redundant role in calcium signaling in chondrocytes.

The species of Pteromalus Swederus in America north of Mexico with a 4:4 mandibular formula, and description of a potential biocontrol agent of the introduced pest Anthonomus rubi (Herbst) (Coleoptera: Curculionidae).

The strawberry blossom weevil, Anthonomus rubi (Herbst) (Coleoptera: Curculionidae), is native to Europe, Asia, and parts of North Africa, and has recently established in British Columbia, Canada and Washington State, USA. To determine whether any parasitoids in British Columbia parasitize this recently-established pest, A. rubi-infested buds of Rosaceous host plants were collected and reared for parasitoid emergence.

Rejection of Federal Guidance by Southern US States and Projected Consequences for Ending the HIV Epidemic.

Evidence-based HIV programming focused on populations at risk of HIV is critical for sustainable disease prevention. In response to the Tennessee Department of Health decision to reject federal HIV guidance, the present study examines the potential impact of Southern US states adopting policies that direct HIV prevention and testing efforts away from populations "disproportionately affected" (DA) by HIV toward populations "non-disproportionately affected" (NDA). Descriptive and projection analyses with publicly available data explored the influence of policies emphasizing NDA populations on HIV cases.

Dying for help: How mortality salience impacts perceptions of victims.

Terror Management Theory posits that reminders of mortality increase support for cultural values and negative views toward transgressors. However, little research has investigated how mortality salience can influence individuals' perceptions of victims who have suffered differing moral misfortune types. This study explored how mortality salience and moral misfortune types affect the perceptions of victims.

Enzymatic synthesis of aromatic biobased polymers in green, low-boiling solvents.

Given the urge to accelerate the substitution of petrol-derived solvents not only in more traditional fields like pharmaceuticals, personal care, or electronics but also in innovative research processes, this work focuses on the utilisation of four biobased solvents as media for the enzymatic synthesis of aliphatic-aromatic polyesters. As building blocks, the lignin-derived diethyl-2,4-pyridinedicarboxylate was selected as the potentially biobased, aromatic component while more classical diols such as 1,4-butanediol and 1,8-octanediol were used as the aliphatic portion. Results show that among the tested green solvents (cyclohexanone, phenetole, anisole and eucalyptol), the most suitable medium for lipase B from Candida antarctica-catalysed polycondensation reactions was eucalyptol that allowed reach monomer conversions >95 % and number average molecular weights up to 3500 g·mol.