Low-boiling-point perfluorocarbon nanodroplets for adaptable ultrasound-induced blood-brain barrier opening.

Low-boiling point perfluorocarbon nanodroplets (NDs) are valued as effective sonosensitive agents, encapsulating a liquid perfluorocarbon that would instantaneously vaporize at body temperature without the NDs shell. Those NDs have been explored for both therapeutic and diagnostic purposes. Here, phospholipid-shelled nanodroplets containing octafluoropropane (CF) or decafluorobutane (CF) formed by condensation of microbubbles were thoroughly characterized before blood-brain (BBB) permeabilization.

Ensemble optimal interpolation for adjoint-free biogeochemical data assimilation.

Advanced marine ecosystem models can contain more than 100 biogeochemical variables, making data assimilation for these models a challenging prospect. Traditional variational data assimilation techniques like 4dVar rely on tangent linear and adjoint code, which can be difficult to create for complex ecosystem models with more than a few dozen variables. More recent hybrid ensemble-variational data assimilation techniques use ensembles of model forecasts to produce model statistics and can thus avoid the need for tangent linear or adjoint code.