Publications by authors named "J Martinez-Milla"
Article Synopsis
- Type-2 diabetes (T2DM) and arterial hypertension (HTN) are significant risk factors for heart failure, potentially causing combined changes in the heart that may reveal new treatment targets through molecular signaling.
- In a study analyzing cardiac biopsies from patients with coronary heart disease, 677 proteins were significantly altered, with specific changes noted for those with both HTN and T2DM compared to those with only HTN or healthy controls.
- Bioinformatics indicated that mTOR signaling pathways and reduced activation of AMPK and PPARα were linked to these alterations, affecting mitochondrial function and ATP synthesis, highlighting the impact of combined HTN and T2DM on cardiac health.
Aims: Residual congestion at the time of hospital discharge is an important readmission risk factor, and its detection with physical examination and usual diagnostic techniques have strong limitations in overweight and obese patients. New tools like bioelectrical impedance analysis (BIA) could help to determine when euvolaemia is reached. The aim of this study was to investigate the usefulness of BIA in management of heart failure (HF) in overweight and obese patients.
View Article and Find Full Text PDFBackground. Mineral metabolism (MM) system and N-terminal pro-brain natriuretic peptide (NT-ProBNP) have been shown to add prognostic value in patients with stable coronary artery disease (SCAD). However, the influence of NT-ProBNP on the prognostic role of MM in patients with SCAD has not been shown yet.
View Article and Find Full Text PDFAims: Experimental studies suggest that increased bone marrow (BM) activity is involved in the association between cardiovascular risk factors and inflammation in atherosclerosis. However, human data to support this association are sparse. The purpose was to study the association between cardiovascular risk factors, BM activation, and subclinical atherosclerosis.
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