In the period of January of 1985 to January of 1995, 6 cases of massive hypertrophy of the mammary gland were diagnosed from 60,000 patients seen in the External Consultation of the Service of Gynecological Oncology. The age oscillated between 11 and 27 years old, with an average of 20.8 years.
View Article and Find Full Text PDFRabbits subjected to a daily bloodletting schedule of 10 ml blood per kg body weight increase four- or fivefold their erythropoietic production compared to normal non-bled animals. The maximum response they can reach under these conditions mobilizes more than 9 mg of iron per day per rabbit into hemoglobin. When fed ad libitum with their regular diet, they do not need any further iron supplement for full erythropoiesis.
View Article and Find Full Text PDFArch Invest Med (Mex)
April 1993
Rabbit erythropoiesis was studied during recovery from chronic anaemia induced by bleeding. Adult rabbits were made anaemic by daily removal of 10 ml of blood per Kg of body weight, through intracardiac puncture, resulting in a significant stimulation of erythropoiesis. After 14 days, bleeding was stopped and the erythropoietic response was studied during the period of recovery.
View Article and Find Full Text PDF1. An experimental model system was developed in the rabbit to study the transport of iron and the erythropoietic response to chronic bloodletting. 2.
View Article and Find Full Text PDFHaem controls the rate of haem synthesis in erythroid cells by inhibiting iron incorporation from transferrin. The present results indicate that haem primarily inhibits the release of iron from transferrin subsequent to transferrin endocytosis and that the inhibition of transferrin endocytosis caused by relatively high concentrations of haem is a secondary effect. Low concentrations of haem (10-25 microM) significantly inhibit reticulocyte iron uptake and to a greater extent its incorporation into haem, but do not inhibit either the initial rate of transferrin uptake or its internalization by the cells.
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