Publications by authors named "J Marlin"
Human Epidemiology and Response to SARS-CoV-2 (HEROS): objectives, design, and enrollment results of a 12-city remote observational surveillance study of households with children, using direct-to-participant methods.
Am J Epidemiol
October 2024
Article Synopsis
- The HEROS Study is a prospective, multicity research effort conducted from May 2020 to February 2021, aimed at understanding risk factors for SARS-CoV-2 infection and transmission, particularly among children and those with asthma or allergies.
- The study utilized remote methods to enroll participants, who completed weekly surveys and nasal sampling, allowing researchers to gather data without in-person visits during the pandemic.
- A total of 5598 individuals were involved, ensuring a comprehensive household-based analysis of infection and transmission dynamics related to COVID-19.
Human Epidemiology and RespOnse to SARS-CoV-2 (HEROS): Objectives, Design and Enrollment Results of a 12-City Remote Observational Surveillance Study of Households with Children using Direct-to-Participant Methods.
medRxiv
July 2022
Article Synopsis
- The HEROS study was a multi-city, 6-month research project conducted from May 2020 to February 2021, aiming to identify risk factors for SARS-CoV-2 infection and transmission, particularly among children and people with asthma and allergies.
- It utilized remote methods to enroll and monitor participants, including weekly surveys and biweekly nasal samples, ensuring safety and compliance during the pandemic without any in-person interactions.
- A total of 5,598 individuals were enrolled in the study, including children and their caregivers, showcasing a successful model for conducting large-scale observational research during challenging circumstances.
As part of a biannual health examination, coprological samples from 3-mo-old Central American river turtles, Dermatemys mawii (Gray, 1847) in a breeding program in Belize, Central America, revealed a previously undescribed coccidian (Apicomplexa) in 17 of 46 (37%) samples. Of 3 positive fecal samples transported to the University of Florida, coccidian oocysts were observed in 1 sample. Sporulated oocysts were measured and described, and using polymerase chain reaction (PCR), an approximately 400-base pair (bp) region of both the small subunit (18S) ribosomal RNA gene and 1,200-bp region of the internal transcribed spacer (ITS) gene were amplified in all 3 samples and their products were sequenced.
View Article and Find Full Text PDFImportance: Sepsis is a common syndrome with substantial morbidity and mortality. A combination of vitamin C, thiamine, and corticosteroids has been proposed as a potential treatment for patients with sepsis.
Objective: To determine whether a combination of vitamin C, thiamine, and hydrocortisone every 6 hours increases ventilator- and vasopressor-free days compared with placebo in patients with sepsis.
Reciprocal interactions between the prefrontal cortex (PFC) and thalamus play a critical role in cognition, but the underlying circuits remain poorly understood. Here we use optogenetics to dissect the specificity and dynamics of cortico-thalamo-cortical networks in the mouse brain. We find that cortico-thalamic (CT) neurons in prelimbic PFC project to both mediodorsal (MD) and ventromedial (VM) thalamus, where layer 5 and 6 inputs activate thalamo-cortical (TC) neurons with distinct temporal profiles.
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