Publications by authors named "J Mark Elwood"

Purpose: Beta blockers (BBs) are commonly used cardiovascular medications, and their association with breast cancer outcomes has been examined in several previous observational studies and meta-analyses. In this study, an updated meta-analysis was undertaken to ascertain the association between BBs and both breast cancer death (BCD) and breast cancer recurrence (BCR).

Methods: Articles were sourced from various databases up until the 14th of August 2023.

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A one-pot procedure for the oxidative amidation of aldehydes via the generation of reactive nitrile imine (NI) intermediates has been developed. Distinct from our progenitor processes, mechanistic and control experiments revealed that the NI undergoes rapid oxidation to an acyl diazene species, which then facilitates -acylation of an amine. A range of substrates have been explored, including application in the synthesis of pharmaceutically relevant compounds.

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The androgen receptor (AR) is central to prostate cancer pathogenesis and has been extensively validated as a drug target. However, small-molecule anti-androgen therapies remain limited due to resistance and will eventually fail to suppress tumor growth, resulting in progression to castration-resistant prostate cancer (CRPC). The intrinsically disordered N-terminal domain (NTD) is crucial for AR transactivation and has been investigated as a suitable target in the presence of ligand binding domain mutations.

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Article Synopsis
  • There is a growing need for effective management of cardiovascular disease (CVD) risk among cancer survivors, as evidence on this issue remains inconsistent.
  • A study analyzed data from over 446,000 patients, revealing that cancer survivors had a higher risk of CVD hospitalization and death compared to non-cancer patients, with myeloma, lung cancer, and non-Hodgkin lymphoma showing the greatest risks.
  • The findings emphasize the importance of prioritizing CVD risk management for cancer survivors, especially those with specific types of cancer known to have elevated risks.
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Background: Women with early breast cancer who meet guideline-based criteria should be offered breast conserving surgery (BCS) with adjuvant radiotherapy as an alternative to mastectomy. New Zealand (NZ) has documented ethnic disparities in screening access and in breast cancer treatment pathways. This study aimed to determine whether, among BCS-eligible women, rates of receipt of mastectomy or radiotherapy differed by ethnicity and other factors.

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