Publications by authors named "J Marinus"
Digital Health Technology Use Across Socioeconomic Groups Prior to and During the COVID-19 Pandemic: Panel Study.
JMIR Public Health Surveill
September 2024
Background: Digital technologies have become more important in the health care sector in the past decades. This transition from conventional to digital health care has been accelerated by the impact of the COVID-19 pandemic, which poses the risk of creating a "digital divide," inadvertently placing those who are older, economically disadvantaged, and have a lower level of education at a disadvantage.
Objective: This study focuses on the influence of socioeconomic factors on the adoption of digital health technology in the Frisian population and how this relation is affected by the COVID-19 pandemic.
Background: Standardized screening for subthalamic deep brain stimulation (STN DBS) in Parkinson's disease (PD) patients is crucial to determine eligibility, but its utility to predict postoperative outcomes in eligible patients is inconclusive. It is unknown whether wearable data can contribute to this aim.
Objective: To evaluate the utility of universal components incorporated in the DBS screening, complemented by a wearable sensor, to predict motor outcomes and Quality of life (QoL) one year after STN DBS surgery.
Objective: To present a case of refractory medication-induced tremor successfully treated with deep brain stimulation (DBS) of the thalamic ventral intermediate nucleus (Vim) and to propose a medical and surgical treatment algorithm based on a systematical review of the literature.
Methods: Patient data were retrospectively collected. A systematic search was performed in PubMed, Embase, and Cochrane Library.
Article Synopsis
- The study investigates how genetic factors affect the progression of Parkinson's disease (PD) to dementia, which significantly impacts patients' quality of life.
- A genome-wide survival analysis was conducted on 3,821 PD patients, uncovering RIMS2 as a key genetic locus linked to disease progression, along with suggestive evidence for TMEM108 and WWOX.
- While polygenic scores related to progression show a strong association with dementia risk, susceptibility scores do not predict outcomes, highlighting different genetic mechanisms for PD progression versus susceptibility.
Objective: Parkinson's disease (PD) is a complex neurodegenerative disorder. Men are on average ~ 1.5 times more likely to develop PD compared to women with European ancestry.
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