Publications by authors named "J Manuel Garcia-Verdugo"
Article Synopsis
- - Germinal matrix hemorrhage (GMH) is a serious condition in preterm infants linked to blood vessel rupture in the brain, but the reasons behind this vulnerability are not well understood.
- - Research shows that microglia (immune cells in the brain) interact with developing blood vessels differently as the brain matures and their absence can hinder blood vessel growth in key brain areas.
- - In preterm infants with GMH, immune cells show abnormal activation, leading to inflammation and factors that compromise blood vessel integrity, suggesting that the immune response plays a crucial role in the development of GMH.
Article Synopsis
- Preterm infants often need oxygen right after birth, but too much oxygen can harm their developing lungs due to harmful free radicals.
- Research using a mouse model tested how different oxygen levels during pregnancy affect lung health after exposure to high levels of oxygen at birth.
- The study found that exposing mice to low oxygen before birth protected their lungs from damage during high oxygen exposure after birth, indicating hypoxic preconditioning could improve postnatal lung development.
Article Synopsis
- ALS is a neurodegenerative disorder that affects both motor neurons and skeletal muscle, with muscle metabolic disruptions appearing before the onset of classic symptoms.
- Research found that ALS muscle cells show impaired myogenesis and glucose oxidation, linked to the FOXO1 transcription factor, suggesting this factor plays a critical role in the disease's muscle-related issues.
- Targeting FOXO1 may offer a new therapeutic strategy for ALS by improving muscle function and potentially alleviating some symptoms associated with the disorder.
Article Synopsis
- Mutations in the () gene cause a serious metabolic condition leading to symptoms like seizures, psychomotor delays, and severe lactic acidosis due to lipoylation defects in key enzyme complexes.
- Research using patient-derived fibroblasts and neurons revealed reduced levels of essential proteins and enzyme activities, resulting in cellular energy failure and damage.
- A combination of antioxidants and mitochondrial boosters was found to improve cell function and protein lipoylation, suggesting a potential treatment strategy for this genetic disorder, primarily through SIRT3 activation.
Neurogenesis and gliogenesis continue in the Ventricular-Subventricular Zone (V-SVZ) of the adult rodent brain. B1 cells are astroglial cells derived from radial glia that function as primary progenitors or neural stem cells (NSCs) in the V-SVZ. B1 cells, which have a small apical contact with the ventricle, decline in numbers during early postnatal life, yet neurogenesis continues into adulthood.
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