Particulate matter from both heavy fuel oil and diesel fuel shipping emissions show strong biological effects on human lung cells at realistic and comparable in vitro exposure conditions.

Background: Ship engine emissions are important with regard to lung and cardiovascular diseases especially in coastal regions worldwide. Known cellular responses to combustion particles include oxidative stress and inflammatory signalling.

Objectives: To provide a molecular link between the chemical and physical characteristics of ship emission particles and the cellular responses they elicit and to identify potentially harmful fractions in shipping emission aerosols.

Combining metabolomic non-targeted GC×GC-ToF-MS analysis and chemometric ASCA-based study of variances to assess dietary influence on type 2 diabetes development in a mouse model.

Insulin resistance (IR) lies at the origin of type 2 diabetes. It induces initial compensatory insulin secretion until insulin exhaustion and subsequent excessive levels of glucose (hyperglycemia). A high-calorie diet is a major risk factor contributing to the development of this metabolic disease.

An evaluation of the "GGP" personal samplers under semi-volatile aerosols: sampling losses and their implication on occupational risk assessment.

Semi-volatile (SV) aerosols still represent an important challenge to occupational hygienists due to toxicological and sampling issues. Particularly problematic is the sampling of hazardous SV that are present in both particulate and vapour phases at a workplace. In this study we investigate the potential evaporation losses of SV aerosols when using off-line filter-adsorber personal samplers.

Spatial and temporal variability of source contributions to ambient PM10 during winter in Augsburg, Germany using organic and inorganic tracers.

Daily PM10 samples were collected during a one-month sampling campaign from February 13 to March 12, 2008 at eight different sampling sites in Augsburg, Southern Germany. Source apportionment was performed to identify the main sources and related contributions by analysis of organic and inorganic tracers. Nine factors were separated comprising: solid fuel combustion, traffic-related emissions, secondary inorganics, and mixed sources.

The impact of blood on liver metabolite profiling - a combined metabolomic and proteomic approach.

Metabolomics has entered the well-established omic sciences as it is an indispensable information resource to achieve a global picture of biological systems. The aim of the present study was to estimate the influence of blood removal from mice liver as part of sample preparation for metabolomic and proteomic studies. For this purpose, perfused mice liver tissue (i.