Publications by authors named "J Mannion"

Pulsed field ablation uses irreversible electroporation to interrupt cellular membranes and induce myocyte apoptosis. Reversible electroporation has been used in other specialties, but its utility in cardiac ablation is unknown. Here, a 69-year-old woman undergoing repeat ablation for atypical atrial flutter presented with extensive scar after cardiac surgery (including MAZE) and previous ablation, leading to a macro re-entry circuit.

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Type 2 immunity represents a unique immune module that provides host protection against macro-parasites and noxious agents such as venoms and toxins. In contrast, maladaptive type 2 immune responses cause allergic diseases. While multiple cell types play important roles in type 2 immunity, recent studies in humans and murine models of chronic allergic diseases have shown that a distinct population of tissue-resident, CD4+ T helper type 2 (Th2) cells play a critical role in chronic allergic inflammation.

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The cellular concentrations of splicing factors (SFs) are critical for controlling alternative splicing. Most serine and arginine-enriched (SR) protein SFs regulate their own concentration via a homeostatic feedback mechanism that involves regulation of inclusion of non-coding 'poison exons' (PEs) that target transcripts for nonsense-mediated decay. The importance of SR protein PE splicing during animal development is largely unknown despite PE ultra-conservation across animal genomes.

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