[Loincloths and health prevention].

The authors report on activities carried out in the 1990s in Côte d'Ivoire using original AIDS prevention methods. These initiatives were based on the use of loincloths. The loincloth is a printed fabric that is highly valued in Africa.

Gene therapy rescues brain edema and motor function in a mouse model of megalencephalic leukoencephalopathy with subcortical cysts.

Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is an ultrarare, infantile-onset leukodystrophy characterized by white matter edema for which there is no treatment. More than 70% of diagnosed cases result from biallelic loss-of-function mutations in the astrocyte-specific gene MLC1, leading to early-onset macrocephaly, cerebellar ataxia, epilepsy, and mild cognitive decline. To develop a gene therapy for MLC, we administered an adeno-associated viral vector capable of crossing the murine blood-brain barrier, delivering the human MLC1 cDNA under the control of a human astrocyte-specific promoter, to 10-month-old Mlc1 mice.

Uniformed Medical Student Perspectives About Mental Health: Thematic Analysis of Written Reflections.

Introduction: Medical students, including uniformed medical students, are at greater risk of depression, anxiety, and burnout compared to their age-matched peers, yet relatively few medical students choose to seek help from mental health professionals. This study aimed to evaluate medical students' reflective writings to identify common themes and attitudes around mental health-for both the medical students themselves and how they view their future patients.

Materials And Methods: Written reflections on the topic of mental health were completed during a required pre-clerkship reflective practice course.

Neoadjuvant paclitaxel/olaparib in comparison to paclitaxel/carboplatin in patients with HER2-negative BC and HRD -long-term survival of the GeparOLA study.

Backgound: The GeparOLA study evaluated paclitaxel(P) plus olaparib(O) in neoadjuvant chemotherapy (NACT) for patients with HER2-negative early breast cancer (eBC) with homologous recombination deficiency (HRD). HRD was defined by high HRD-score or germline(g)/tumor(t) BRCA1/2 mutations (g/tBRCA1/2mut). Here, we report long-term outcome data.

Structural basis for HIV-1 capsid adaption to rescue IP6-packaging deficiency.

Inositol hexakisphosphate (IP6) promotes HIV-1 assembly via its interaction with the immature Gag lattice, effectively enriching IP6 within virions. During particle maturation, the HIV-1 protease cleaves the Gag polyproteins comprising the immature Gag lattice, releasing IP6 from its original binding site and liberating the capsid (CA) domain of Gag. IP6 then promotes the assembly of mature CA protein into the capsid shell of the viral core, which is required for infection of new target cells.