Publications by authors named "J Malm"
Background: Melanoma is a highly heterogeneous disease, and a deeper molecular classification is essential for improving patient stratification and treatment approaches. Here, we describe the histopathology-driven proteogenomic landscape of 142 treatment-naïve metastatic melanoma samples to uncover molecular subtypes and clinically relevant biomarkers.
Methods: We performed an integrative proteogenomic analysis to identify proteomic subtypes, assess the impact of BRAF V600 mutations, and study the molecular profiles and cellular composition of the tumor microenvironment.
Respiratory influence on cerebral blood flow and blood volume - A 4D flow MRI study.
J Cereb Blood Flow Metab
January 2025
Variations in cerebral blood flow and blood volume interact with intracranial pressure and cerebrospinal fluid dynamics, all of which play a crucial role in brain homeostasis. A key physiological modulator is respiration, but its impact on cerebral blood flow and volume has not been thoroughly investigated. Here we used 4D flow MRI in a population-based sample of 65 participants (mean age = 75 ± 1) to quantify these effects.
View Article and Find Full Text PDFBackground: Prostate cancer therapy with surgical or chemical castration with gonadotropin-releasing hormone (GnRH) agonists has been linked to elevated follicle-stimulating hormone (FSH) levels, which may contribute to secondary health disorders, including atherosclerosis and diabetes. Although recent findings suggest a role for FSH beyond the reproductive system, its metabolic impact remains unclear and difficult to disentangle from that of androgens. In this study, we examined the metabolic changes induced by FSH and distinguished them from those caused by testosterone.
View Article and Find Full Text PDFBackground: The utilization of PD1 and CTLA4 inhibitors has revolutionized the treatment of malignant melanoma (MM). However, resistance to targeted and immune-checkpoint-based therapies still poses a significant problem.
Objective: Here, we mine large-scale MM proteogenomic data to identify druggable targets and forecast treatment efficacy and resistance.
Article Synopsis
- Selective antegrade cerebral perfusion (SACP) is a technique used to maintain brain blood flow during aortic arch surgeries that require temporary stopping of blood circulation, with two methods: bilateral (bSACP) and unilateral (uSACP), each having its risks.
- A new predictive method was developed and tested to determine cerebral perfusion pressures (CPP) during SACP, helping surgeons decide which SACP approach to use preoperatively, utilizing patient-specific imaging and simulations.
- The study involved five patients and demonstrated that the prediction method was accurate, with minimal errors in CPP predictions, highlighting the importance of collateral artery size for accurate modeling in surgical planning.