Publications by authors named "J Malcolm Walker"

Geologic records of tropical cyclones (TCs) in low-energy, back-barrier environments are established by identifying marine sediments via their allochthonous biogeochemical signal. These records have the potential to reconstruct TC intensity and frequency through time. However, modern analog studies are needed to understand which biogeochemical indicators of overwash sediments are best preserved and how post-depositional changes may affect their preservation.

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Motivation: Recent advancements in parallel sequencing methods have precipitated a surge in publicly available short-read sequence data. This has encouraged the development of novel computational tools for the de novo assembly of transcriptomes from RNA-seq data. Despite the availability of these tools, performing an end-to-end transcriptome assembly remains a programmatically involved task necessitating familiarity with best practices.

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Early time-restricted eating (eTRE) is a dietary strategy that restricts caloric intake to the first 6-8 h of the day and can effect metabolic benefits independent of weight loss. However, the extent of these benefits is unknown. We conducted a randomized crossover feeding study to investigate the weight-independent effects of eTRE on glycemic variation, multiple time-in-range metrics, and levels of inflammatory markers.

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Article Synopsis
  • The study investigates the effects of menstrual cycle phases and time of day on various stress and immune biomarkers, including salivary α-amylase (sAA) and secretory immunoglobulin A (SIgA), in a group of 17 participants.
  • No significant interactions were found between menstrual cycle phases and time of day for the biomarkers, resting blood pressure, heart rate, or body composition.
  • However, results indicate that resting heart rate and sAA levels were higher in the afternoon, while SIgA levels were higher in the morning, highlighting the influence of time of day on these markers, rather than the menstrual cycle phases.
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Background: The hippocampus plays a crucial role in memory and is one of the first structures affected by Alzheimer's disease. Postmortem MRI offers a way to quantify the alterations by measuring the atrophy of the inner structures of the hippocampus. Unfortunately, the manual segmentation of hippocampal subregions required to carry out these measures is very time-consuming.

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