Impact of post-traumatic stress disorder on epileptogenic networks: a functional connectivity study.

Post-traumatic stress disorder (PTSD) is more common in patients with drug-resistant epilepsy. Some of these patients experience PTSD due to early psychotraumatic events. This study aims to assess the influence of PTSD on interictal functional connectivity using stereoelectroencephalography (SEEG) recordings in patients with temporal lobe DRE (TDRE).

Working memory deficit in patients with focal epilepsy is associated with higher interictal theta connectivity.

Objective: Interictal cognitive disturbances are frequent in patients with focal epilepsies and the links with alteration of resting state brain oscillations are not well known. Changes in theta oscillations, may contribute to cognitive impairment. This study aimed to investigate whether changes in theta activity are related to cognitive disturbances.

Brain sodium MRI-derived priors support the estimation of epileptogenic zones using personalized model-based methods in epilepsy.

Patients presenting with drug-resistant epilepsy are eligible for surgery aiming to remove the regions involved in the production of seizure activities, the so-called epileptogenic zone network (EZN). Thus the accurate estimation of the EZN is crucial. Data-driven, personalized virtual brain models derived from patient-specific anatomical and functional data are used in Virtual Epileptic Patient (VEP) to estimate the EZN via optimization methods from Bayesian inference.

Transient alteration of Awareness triggered by direct electrical stimulation of the brain.

Background: Awareness is a state of consciousness that enables a subject to interact with the environment. Transient alteration of awareness (AA) is a disabling sign of many types of epileptic seizures. The brain mechanisms of awareness and its alteration are not well known.

Impact of transcranial electrical stimulation on simultaneous stereoelectroencephalography recordings: A randomized sham-controlled study.

Objective: Clinical exploitation of transcranial electrical stimulation for focal epilepsy treatment lacks quantification of the underlying neurophysiological changes. This study explores the immediate effects of transcranial alternating (tACS) and direct (tDCS) current stimulation on local and network brain activity using simultaneous stereoelectroencephalography (SEEG) recordings.

Methods: Patients were randomized for personalized tACS (n = 5) or tDCS (n = 6).