An experimental and theoretical investigation of flow in a gross pollutant trap.

Flow through a gross pollutant trap (GPT) with fully blocked screens is investigated experimentally and theoretically using computational fluid dynamics (CFD). Due to the wide range of possible flow regimes, an experimental approach is developed which uses a downstream weir arrangement to control the nature of the flow and the variation in free surface height. To determine the overall flow structure, measurements are taken at a fixed depth throughout the trap with an Acoustic Doppler Velocimeter (ADV), including velocity profile data across three cross sections of the GPT suitable for more detailed comparison with simulations.

Tissue plasminogen activator (t-PA).

Tissue plasminogen activator (t-PA) developed from recombinant DNA technology is a highly effective thrombolytic agent. Its main clinical application is in the treatment of acute myocardial infarction (MI), with most beneficial results occurring in patients treated early after the onset of symptoms. When t-PA was compared with other thrombolytic agents, such as streptokinase (SK) and anisolyted plasminogen streptokinase (APSAC), the data obtained from the mega trials (GISSI 2 and ISIS 3) revealed no significant difference in mortality.