Publications by authors named "J Mack Aldridge"
Cardiolipin (CL) is an essential phospholipid that supports the functions of mitochondrial membrane transporters and oxidative phosphorylation complexes. Due to the high level of fatty acyl chain unsaturation, CL is prone to peroxidation during aging, neurodegenerative disease, stroke, and traumatic brain or spinal cord injury. Therefore, effective therapies that stabilize and preserve CL levels or enhance healthy CL fatty acyl chain remodeling are needed.
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- Marine sediments are significant carbon stores, but bottom trawl fisheries disturb seabed habitats, potentially impacting the ocean's carbon dioxide sink.
- Research is concerned that trawling may turn these sediments into a significant source of CO, but there's a lot of uncertainty due to limited understanding of how trawling affects sediment mixing and carbon processes.
- A review protocol will investigate the effects of mobile bottom fishing on carbon processing and storage in sediments by addressing various questions about carbon types, fluxes between benthic and pelagic systems, and the biological and physical controls on this carbon.
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- Dravet Syndrome (DS) is a severe epilepsy in children that increases the risk of Sudden Unexpected Death in Epilepsy (SUDEP), often linked to mutations in a specific gene affecting both the brain and heart.
- Research using a DS mouse model revealed significant sex-specific changes in cardiac mitochondrial function, with male mice showing reduced respiratory capacity and increased vulnerability to arrhythmias.
- The study highlights that males are more susceptible to these cardiac issues compared to females, suggesting that therapeutic approaches for SUDEP risk in DS should take sex differences into account.
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- Scientists found special proteins called hydrophobins and cerato-platanins in a sea fungus named Paradendryphiella salina.
- They identified three important genes that make these proteins and studied their properties, like weight and how they behave in water.
- The study shows that this fungus can adapt to living in the ocean and may help in areas like medicine, food, and cleaning up the environment!
plays essential roles in the heart, where it encodes β-subunits that serve as modifiers of gene expression, cell surface channel activity, and cardiac conductivity. Reduced β function is linked to electrical instability in various diseases with cardiac manifestations and increased susceptibility to arrhythmias. Recently, we demonstrated that loss of in mice leads to compromised mitochondria energetics and reactive oxygen species (ROS) production.
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