Publications by authors named "J Macia Virgili"
The relationship between caffeine consumption and cardiometabolic health has been reported, however with heterogenous results. Discrepancies in study results may be due to inter-individual variability between study participants. This systematic review aimed to identify the impact of genetics on the relationship between caffeine consumption and cardiometabolic outcomes.
View Article and Find Full Text PDFObesity and diabetes are strongly associated not only with fatty liver but also cognitive dysfunction. Moreover, their presence, particularly in midlife, is recognized as a risk factor for Alzheimer's disease (AD). AD, the most common cause of dementia, is increasingly considered as a metabolic disease, although underlying pathogenic mechanisms remain unclear.
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- The 3xTg-AD mouse model exhibits Alzheimer's disease-like symptoms, such as amyloid plaques and tau tangles, but lacks significant neuronal loss, suggesting it doesn't fully replicate Alzheimer's neuropathology.
- By crossing 3xTg-AD mice with SAMP8 mice, a model of accelerated aging, the study found that older P8/3xTg-AD mice made significantly more errors in spatial memory tasks compared to other groups, indicating age-related cognitive decline.
- Postmortem analysis revealed increased levels of harmful tau proteins and amyloid in P8/3xTg-AD females, alongside signs of astroglial activation, highlighting the negative impact of aging on Alzheimer's-related pathology without evident
Altered Protein Expression of Cardiac CYP2J and Hepatic CYP2C, CYP4A, and CYP4F in a Mouse Model of Type II Diabetes-A Link in the Onset and Development of Cardiovascular Disease?
Pharmaceutics
October 2017
Arachidonic acid can be metabolized by cytochrome P450 (CYP450) enzymes in a tissue- and cell-specific manner to generate vasoactive products such as epoxyeicosatrienoic acids (EETs-cardioprotective) and hydroxyeicosatetraenoic acids (HETEs-cardiotoxic). Type II diabetes is a well-recognized risk factor for developing cardiovascular disease. A mouse model of Type II diabetes (C57BLKS/J-) was used.
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