Publications by authors named "J Macho"

Background/purpose: Flow diverter porosity directly influences the blood flow reduction at the aneurysm neck level and the anatomical result of the treatment. In this research, we present and compare three methodologies to determine the local porosity of deployed flow diverters.

Method: Three-dimensional rotational angiography was used to obtain computational vessel models of three patients.

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Article Synopsis
  • A new computational tool is introduced for guiding the treatment of intracranial aneurysms by combining preoperative simulation data with real-time X-Ray images during surgery.
  • The tool allows for optimal selection and positioning of flow diverter (FD) devices by aligning 3D models of the vessels with 2D-X-Ray scans, enabling surgeons to visually assess the device’s deployment.
  • Validation of the approach showed a high accuracy in positioning, with a minor average difference of 0.832 mm between simulated and actual device locations, ultimately supporting safer surgical decisions.
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Oral squamous cell carcinoma (OSCC) is the most frequent type of cancer of the head and neck area accounting for approx. 377,000 new cancer cases every year. The epithelial-to-mesenchymal transition (EMT) program plays an important role in OSCC progression and metastasis therefore contributing to a poor prognosis in patients with advanced disease.

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Introduction: The iNedit balloon distal access catheter is a novel thrombectomy device. It has an inner diameter of 0.058″, proximal outer diameter of 2.

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