Publications by authors named "J MacKintosh"
Background: Lung function testing remains a cornerstone in the assessment and management of interstitial lung disease (ILD) patients. The clinical implications of the Global Lung function Initiative (GLI) reference equations and the updated interpretation strategies remain uncertain.
Methods: Adult patients with ILD with baseline forced vital capacity (FVC) were included from the Australasian ILD registry and the National Healthcare Group ILD registry, Singapore.
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome is a rare and recently identified disease resulting from a somatic mutation in the X-linked UBA1 gene in cells of myeloid lineage. It can present in a myriad of ways with the potential to affect various organ systems, including the lungs. VEXAS is usually steroid responsive, but no strong data exists for the use of a steroid-sparing agent.
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- - The study investigates pulmonary fibrosis, a condition where lung tissue becomes damaged, by classifying patients based on blood biomarkers to identify different disease types, or endotypes.
- - Researchers used data from the PROFILE study, involving a group of UK patients, to perform cluster analysis and measure 13 specific blood biomarkers related to lung tissue health.
- - The analysis revealed three distinct patient clusters that correlate with different biomarker levels, providing insights into disease patterns and their associations with mortality and lung function decline.