Publications by authors named "J M van Deursen"
Life stress can shorten lifespan and increase risk for aging-related diseases, but the biology underlying this phenomenon remains unclear. Here we assessed the effect of chronic stress on cellular senescence-a hallmark of aging. Exposure to restraint stress, a psychological non-social stress model, increased p21 exclusively in the brains of male, but not female mice, and in a p16-independent manner.
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- HD-PTP (or PTPN23) plays a key role in the formation of multivesicular bodies by aiding endosomal sorting complexes, which is important for cellular transport.
- Researchers created mice with reduced HD-PTP levels to study its physiological effects, discovering these mice displayed lipodystrophy and impaired signaling in white adipose tissue related to various pathways, including RAS/MAPK and PI3K/AKT.
- The study found that while EGF binding was normal, there was reduced signaling activation due to changes in cholesterol distribution within cells, suggesting a crucial role for HD-PTP in both signaling regulation and maintaining fat tissue health.
Objective: Despite advances toward understanding the etiology of Alzheimer's disease (AD), it remains unclear which aspects of this disease are affected by environmental factors. Chronic life stress increases the risk of aging-related diseases including AD. The impact of stress on tauopathies remains understudied.
View Article and Find Full Text PDFPTEN is a multifaceted tumor suppressor that is highly sensitive to alterations in expression or function. The PTEN C-tail domain, which is rich in phosphorylation sites, has been implicated in PTEN stability, localization, catalytic activity, and protein interactions, but its role in tumorigenesis remains unclear. To address this, we utilized several mouse strains with nonlethal C-tail mutations.
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