Publications by authors named "J M den Harder"
Mutations in SARS-CoV-2 variants of concern (VOCs) have expanded the viral host range beyond primates, and a few other mammals, to mice, affording the opportunity to exploit genetically diverse mouse panels to model the broad spectrum of responses to infection in patient populations. Here we surveyed responses to VOC infection in genetically diverse Collaborative Cross (CC) founder strains. Infection of wild-derived CC founder strains produced a broad range of viral burden, disease susceptibility and survival, whereas most other strains were resistant to disease despite measurable lung viral titers.
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- Researchers are exploring keratinocytes (KCs) from patients with atopic dermatitis (AD) to study inflammatory responses, suggesting they may better represent AD conditions than KCs from healthy individuals.
- * The study found that KCs from AD patients showed greater expression of AD-related markers when stimulated with cytokines IL-4 and IL-13 compared to those from healthy donors.
- * Hair follicle-derived KCs from AD patients provide a promising noninvasive model for understanding AD-related inflammation and can mimic the disease's features in laboratory setups.
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- About 22% of patients with moderate to severe atopic dermatitis have experienced eczema herpeticum, an infection primarily caused by the herpes simplex virus type 1 (HSV-1), potentially due to reduced antimicrobial peptide activity.
- This study found that the antimicrobial protein RNase 7 can limit HSV-1 infection in human skin cells (keratinocytes) by inhibiting gene expression and viral genome replication without relying on added DNA for stimulation.
- RNase 7 acts on intracellular processes of infection rather than affecting how the virus binds to cells, suggesting that its reduced activity in atopic dermatitis may increase the risk of developing eczema herpeticum.
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- Corticosteroids, known for their anti-inflammatory properties, may be helpful in treating peripheral nerve injuries, despite limited current use.
- A systematic review of studies revealed that corticosteroids can provide pain relief and support nerve regeneration in conditions like cubital tunnel syndrome and chronic inflammatory demyelinating polyradiculoneuropathy.
- While promising, the research suggests more clinical trials are needed to fully understand the potential benefits and safety of corticosteroid treatment for peripheral nerve pathologies.
Hypothesis/background: Patient-specific implants have become an increasingly researched area to improve surgical outcomes. Patient-specific implants have been suggested to provide advantages for better implant alignment and thus improve surgical outcomes. One such area for application is in the use of intramedullary nails for humeral fracture stabilization.
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