Publications by authors named "J M de Gournay"
Article Synopsis
- Relapse after stopping immunosuppression treatment is common in Autoimmune Hepatitis (AIH) patients, and there's a need for better non-invasive biomarkers to predict this risk.
- The study analyzed blood samples from 58 active AIH patients, 56 in remission, and 31 with NASH, focusing on the levels of activated T cell subsets and the cytokine BAFF.
- Results showed that increased frequencies of certain activated T cells and high BAFF levels in remission patients were strongly linked to a higher chance of relapse after treatment withdrawal, suggesting these could serve as useful biomarkers for monitoring AIH.
Article Synopsis
- Detecting autoantibodies is crucial for diagnosing autoimmune hepatitis (AIH), especially in children where their specificity can be lower; recent research points to polyreactive IgG (pIgG) as a promising marker.
- A study, using samples from multiple European centers, found that pIgG had enhanced specificity and accuracy for diagnosing pediatric AIH compared to traditional antibodies like ANA and anti-SMA.
- pIgG distinguished AIH from other liver diseases with an AUC of 0.900, showing it was positive in a significant portion of pediatric patients and independent of their treatment response.
Article Synopsis
- - A study reported on five patients with myeloid neoplasms who experienced liver complications, with liver biopsies showing that their liver sinusoids were blocked by platelet clumps and evidence of extramedullary hematopoiesis.
- - The group included four men and one woman, ages 50 to 82, diagnosed with various haematological disorders, such as myeloproliferative neoplasms and chronic myelomonocytic leukaemia.
- - All patients had severe liver issues, leading to different causes of death within 2 to 23 months post-biopsy, including acute myeloblastic leukaemia and portal hypertension, suggesting that microthromboses could lead to liver complications
Article Synopsis
- Transcatheter arterial chemoembolisation (TACE) is used for treating liver cancer patients who can't undergo curative therapies; this study compared TACE alone with TACE combined with external conformal radiotherapy (CRT).
- The trial involved 120 participants, mostly older males with alcohol-related liver issues, and aimed to assess liver progression-free survival (PFS) over 12 and 18 months.
- Results indicated that while the combined treatment (TACE + CRT) showed better local control, it did not significantly improve PFS or overall survival compared to TACE alone, and led to more serious liver-related side effects.
Article Synopsis
- Heavy alcohol consumption is known to negatively affect survival in patients with alcohol-related cirrhosis, but new research aims to clarify long-term outcomes and recurrence factors.
- The study included 650 patients, highlighting that 30.9% of those who stopped drinking relapsed, with risks being higher for individuals with drug abuse history or shorter abstinence periods.
- Key predictors of survival include age, baseline alcohol consumption, platelet count, and a Child-Pugh score >5, emphasizing that even moderate alcohol intake post-diagnosis can significantly impact health outcomes.
