Publications by authors named "J M Workman"
The CDK4/6 inhibitor Ribociclib has shown limited efficacy as a monotherapy in colorectal cancer (CRC). However, combining Ribociclib with targeted therapies could present a viable strategy for treating CRC. This study evaluated the combination of Ribociclib and the PI3K inhibitor Alpelisib across four distinct cell lines representing different mutational statuses ( wild-type, -mutated, -mutated, and -mutated).
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- The study aimed to identify clinical signs in pediatric patients that could indicate potential future sepsis hospitalizations after visiting the emergency department (ED).
- Using a database analysis method, researchers found that among 184,157 sepsis admissions, 15,331 were preceded by a recent ED visit, with fever and dehydration being common indicators.
- The findings suggest that fever and dehydration could signal upcoming sepsis cases, highlighting the potential for improved diagnostic strategies in pediatric emergency care.
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- The Linearbandkeramik (LBK) Neolithic communities were pioneers in spreading agriculture across Europe and this study showcases genetic data from 250 individuals to understand their ancestry.
- The findings reveal a notable difference in ancestry, with eastern LBK sites having a higher percentage of western hunter-gatherer genetics compared to western sites, indicating separate genetic paths for these groups.
- Additionally, the research suggests a patrilocal social structure, featuring more genetic connections among males within sites, and points out that the massacre at Asparn-Schletz likely involved individuals from a large population rather than a small community.
Delivering ribonucleoproteins (RNPs) for in vivo genome editing is safer than using viruses encoding for Cas9 and its respective guide RNA. However, transient RNP activity does not typically lead to optimal editing outcomes. Here we show that the efficiency of delivering RNPs can be enhanced by cell-penetrating peptides (covalently fused to the protein or as excipients) and that lipid nanoparticles (LNPs) encapsulating RNPs can be optimized for enhanced RNP stability, delivery efficiency and editing potency.
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- The increase in Fragile X disorders (FXD) and immune-related issues indicates that factors beyond genetic mutations are involved in the disease's development.
- New findings show that altered expression and splicing of transposon element (TE)-derived genes that affect purine metabolism and immune responses to viruses are present in FXD patients.
- These TE-derived genes have a higher proportion of specific dinucleotides, resembling some RNA viruses, suggesting that previous viral infections may have influenced the immune disorders seen in FXD.