Publications by authors named "J M Wojcicki"
High school diploma is associated with longer postpartum leukocyte telomere length in a cohort of primarily Latina women.
Matern Health Neonatol Perinatol
December 2024
Article Synopsis
- This study examines how factors like maternal health, diet during pregnancy, and education level impact the length of leukocyte telomeres in mothers shortly after childbirth, focusing on a group of primarily Latina women.
- Researchers collected blood samples from these mothers within 24 hours of delivery and analyzed them using a specific laboratory technique called qPCR to assess telomere length.
- Results show that older maternal age is linked to shorter telomeres, while having a high school diploma correlates with longer telomeres, suggesting that education might reflect exposure to stress and socioeconomic status in determining maternal telomere length.
Objective: To evaluate the performance of childhood obesity prediction models in four independent cohorts in the United States, using previously validated variables obtained easily from medical records as measured in different clinical settings.
Study Design: Data from four prospective cohorts, Latinx, Eating, and Diabetes; Stress in Pregnancy Study; Project Viva; and Center for the Health Assessment of Mothers and Children of Salinas were used to test childhood obesity risk models and predict childhood obesity by ages 4 through 6, using five clinical variables (maternal age, maternal prepregnancy body mass index, birth weight Z-score, weight-for-age Z-score change, and breastfeeding), derived from a previously validated risk model and as measured in each cohort's clinical setting. Multivariable logistic regression was performed within each cohort, and performance of each model was assessed based on discrimination and predictive accuracy.
Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease among US children. Studies have associated food insecurity with MASLD in adults, but there are few studies of pediatric MASLD, particularly in high-risk populations. We assessed the impact of household food insecurity at 4 years of age on MASLD in Latinx children.
View Article and Find Full Text PDFObjective: To assess in utero exposures associated with leukocyte telomere length (LTL) at birth and maternal LTL in a primarily Latinx birth cohort.
Study Design: Mothers and newborns were recruited postnatally before 24 h of life. Newborn LTL was collected via heelstick at birth and maternal LTL was collected postnatally.
Objective: To examine changes in leukocyte telomere length (LTL) during and after a behavioural weight control program for children with obesity.
Methods: We measured LTL among a cohort of 158 children 8-12 years of age with a body mass index greater than or equal to the 95th percentile for age and sex. Children were 55% female, 29% white, 52% Latinx, 8% Asian and 11% Pacific Islander, other or multiethnic.